Yangzhou University "second-generation clone sheep" pregnancy

A few days ago, Yangzhou University in Jiangsu made a significant breakthrough in cloning sheep technology. One of the first-generation cloned sheep carrying human genes has become pregnant, marking a major milestone in China's biotechnology field. This development indicates that the country's cloned sheep have successfully transitioned from asexual to sexual reproduction, opening up new possibilities for genetic research and medical applications. According to Professor Yong Cheng from the Animal Husbandry and Veterinary Institute at Yangzhou University, the university's genetically modified cloned sheep project started back in 1999. At that time, 12 cloned sheep were born, and eight of them survived. To date, the university has successfully bred a total of 20 cloned sheep, including both first- and second-generation offspring, with 16 of them still alive today. The key difference between the first and second generations lies in their genetic origins. The first generation was cloned from somatic cells of a transgenic goat fetus, which is different from the method used for Dolly the sheep, who was cloned from adult sheep cells. The success rate of this technique was significantly higher—about 10 to 20 times better than Dolly’s. In contrast, the second-generation cloned sheep at Yangzhou University were created by genetically modifying ordinary goat cells into a cloned sheep. So far, scientists have detected the presence of the human "lactoferrin" gene in four of these second-generation sheep. If fully successful, lactoferrin extracted from the milk of these goats could be widely used in pharmaceuticals and health products, offering potential benefits in immune support, wound healing, and more. This advancement not only highlights China's growing expertise in genetic engineering but also brings us one step closer to practical, real-world applications of cloning technology.

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