Ganoderma lucidum physiological disease

Due to the non-biological factors, the physiological metabolism of Ganoderma lucidum often leads to diseases.

Symptoms of physiological disease, it will grow deformed zhizhi, mycelium growth or poor growth atrophy, there are leggy phenomenon.

Etiology Due to improper management in cultivation, resulting in malnutrition of the body; excessive or low temperature in the cultivation room, poor ventilation; excessive or low pH of the culture material; unfavorable lightness; poor light coordination; Harmful gases; improper use of pesticides and growth regulators. The hyphae are not mature and prematurely covered with soil. The proportion of nitrogen contained in the culture material is too high, which can easily cause mycelium growth.

Control methods

(1) Strengthen cultivation management, timely ventilation and ventilation, maintain proper temperature and humidity, and pay attention to environmental sanitation.

(2) Choose high-quality strains; reasonably prepare the culture materials, and require proper nitrogen content. The commonly used wheat bran or rice bran should not exceed 20% in general so as to prevent the hyphae from being prolonged;

(3) The boring machine can be sprayed with lime water ranging from 1% to 3%. After the surface is slightly dry, coverings such as branches and branches can be covered, and the hyphae can also be prevented from becoming excessively long.

(4) Select suitable pesticides and growth regulators to prevent pesticide poisoning.

Palbociclib Intermediates

Palbociclib is a drug for the treatment of ER-positive and HER2-negative breast cancer developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
It was reviewed and approved under the Food and Drug Administration`s (FDA) accelerated Priority Review and Breakthrough Therapy designation programs on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor positive advanced breast cancer.
We produce a series of complete intermediates for Palbociclib, intermediate I (CAS No. 571188-59-5), intermediate II (CAS No. 1013916-37-4) and intermediate III (CAS No. 1016636-76-2) etc.

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Pharmaceutical Intermediates

Palbociclib Intermediates,Cas 571188-59-5,Cas 1013916-37-4,Cas 1016636-76-2

Nanjing Sunshine Biotech Co., Ltd , https://www.sunshine-bio.com